Severe isoniazid-associated hepatitis--New York, 1991-1993.
نویسندگان
چکیده
In November 1992, the New York State Department of Health was notified of a patient who underwent liver transplantation because of severe hepatitis that developed during the use of isoniazid (INH) preventive therapy (IPT) for latent tuberculous infection. Inquiry at liver transplant centers in New York revealed other patients who had hepatitis attributed to INH. This report summarizes findings of the ongoing investigation into the extent and causes of this problem.
منابع مشابه
Fatal and severe hepatitis associated with rifampin and pyrazinamide for the treatment of latent tuberculosis infection--New York and Georgia, 2000.
One of the recommended treatments for latent tuberculosis infection (LTBI) is a 9-month regimen of isoniazid (INH); a 2-month regimen of rifampin (RIF) and pyrazinamide (PZA) is an alternative in some instances. In September 2000, a man in New York died of hepatitis after 5 weeks of RIF-PZA, and in December, a woman in Georgia was admitted to a hospital because of hepatitis after 7 weeks of thi...
متن کاملBronchioloalveolar Carcinoma Accompanied by Severe
1 Beck-Sague C, Dooley SW, Hutton MD, et al. Hospital outbreak of multidrug-resistant Mycobacterium tuberculosis infections: factors in transmission to staff and HIV-infected patients. JAMA 1992; 268:1280-86 2 Pierce JR, Sims SL, Holman GH. Tranasmission oftuberculosis to hospital workers by a patient with AIDS. Chest 1992; 101:581-82 3 Centers for Disease Control and Prevention. Nosocomial tra...
متن کاملImprovedDye-BindingProcedure for DeterminIngMicrogram Quantitiesof ProteinIn CerebrospinalFluid-Once
3. Black M, Mitchell JR, Zimmerman HJ, et al. Isomazid-associated hepatitis in 114 patients. Gastroenterology 69, 289-302 (1975). 4. Riska N. Hepatitis casesin NH-treated groups and in a control group. Bull mt Union Tuberc 51, 203-208 (1976). 5. Gronhagen-Riska C, Hellstrom P-E, Froseth B. Predisposing factors in hepatitis induced by isoniazid-rifampin treatment of tuberculosis. Am Rev Respir D...
متن کاملBCG vaccination against tuberculosis: international perspectives.
Mortality in these outbreaks has been high, and measures to control tuberculosis are therefore being urgently reviewed in the United States. In the Medical Research Council's surveys of notifications of tuberculosis in or more of initial isolates of M tuberculosis from respiratory specimens from previously untreated patients were fully sensitive to isoniazid, rifampicin, ethambutol, and strepto...
متن کاملIsoniazid Tablets, USP
Severe and sometimes fatal hepatitis associated with isoniazid therapy has been reported and may occur or may develop even after many months of treatment. The risk of developing hepatitis is age related. Approximate case rates by age are: less than 1 per 1,000 for persons under 20 years of age, 3 per 1,000 for persons in the 20 to 34 year age group, 12 per 1,000 for persons in the 35 to 49 year...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- MMWR. Morbidity and mortality weekly report
دوره 42 28 شماره
صفحات -
تاریخ انتشار 1993